MicroSeq™
On the spot sequencer.
This project was in response to the Ebola outbreak in Sierra Leone. There were no easy ways to sequence in hot spots due to lack of infrastructure. Current instruments were not portable, reagents were fragile, and required internet connection. These requirements posed challenges in developing nations.
My responsibility was leading the design from initial sketches to functional prototypes.
This project initiated small form factor sequencers in the current Illumina product lineup.
Current challenges
Lacking Infrastructure
Basic necessities such as sterile labs, refrigeration, and internet maybe a challenge in developing nations. Therefore this sequencer needed to address those potential issues.
Not portable
Current sequencers are not portable. They need to be packed, crated and need to wait for customs to approve. This additional cost and time would potentially hamper progress.
Fragile chemistry
Currently reagents come in many vials, tubes, and cartridges. Different reagents will need to be stored in different temperatures. If left out, reagents will degrade.
Keeping it simple and practical
Cartridge engagement exploration
Collaborating with engineers to explore different methods on how to engage the cartridge. The goal was for users to simply dock/insert the cartridge and load the sample.
Mockups
Created foam mockups to share with engineering.
Proposed design
Reagents contained in a compact unit. No need for refrigeration.
Cartridges are based on specific diseases.
